| ncRNA name | hsa-miR-145-5p |
| ncRNA Category | miRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM samples, normal uveal samples; human UM cell lines OCM-1 and MUM2B |
| Methods | microarray, qRT-PCR, Western blot, luciferase reporter assay, knockdown |
| Expression pattern | down-regulated |
| Functional description | Overexpression of miR-145 suppressed cell proliferation by blocking the G1 phase entering S phase in uveal melanoma cells, and promoted uveal melanoma cell apoptosis. IRS-1 was identified as a potential target of miR-145 by dual luciferase reporter assay. |
| PubMed ID | 24762580 |
| Year | 2014 |
| Title | MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.